Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome

Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Spliceosome

BackgroundTumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase system. We investigated the role of MG and Glo1 in cancer chemotherapy related in mu...

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Bibliographic Details
Main Authors: Muhanad Alhujaily, Hafsa Abbas, Mingzhan Xue, Alberto de la Fuente, Naila Rabbani, Paul J. Thornalley
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Oncology
Subjects:
methylglyoxal
glyoxalase
cancer chemotherapy
multidrug resistance
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.748698/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.748698/full

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