Synthesis, computational studies and biological evaluation of novel Acenaphthoquinone-imidazole derivatives as dual inhibitors of HSP90 and Topo II in cancer therapy
In this study, titled compounds (4a-4j) were synthesized by employing one-pot multicomponent reaction. To evaluate the binding affinity of derivatives against topo II/Hsp90 performed insilico molecular simulations. Using web tools ADMET and drug-likeness properties were predicted. The conjugation in...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623000358 |