Accelerated high fidelity prion amplification within and across prion species barriers.
Experimental obstacles have impeded our ability to study prion transmission within and, more particularly, between species. Here, we used cervid prion protein expressed in brain extracts of transgenic mice, referred to as Tg(CerPrP), as a substrate for in vitro generation of chronic wasting disease...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2008-08-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC2516356?pdf=render |