PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans

Abstract Cardiac energy status, measured as phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio with 31P-Magnetic Resonance Spectroscopy (31P-MRS) in vivo, is a prognostic factor in heart failure and is lowered in cardiometabolic disease. It has been suggested that, as oxidative phosphorylation...

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Bibliographic Details
Main Authors: Vera H. W. de Wit-Verheggen, Vera B. Schrauwen-Hinderling, Kim Brouwers, Johanna A. Jörgensen, Gert Schaart, Anne Gemmink, Emmani B. M. Nascimento, Matthijs K. C. Hesselink, Joachim E. Wildberger, Patrique Segers, David Montaigne, Bart Staels, Patrick Schrauwen, Lucas Lindeboom, Joris Hoeks, Tineke van de Weijer
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-35041-7