Early Age- and Sex-Dependent Regulation of Astrocyte-Mediated Glutamatergic Synapse Elimination in the Rat Prefrontal Cortex: Establishing an Organotypic Brain Slice Culture Investigating Tool

Early Age- and Sex-Dependent Regulation of Astrocyte-Mediated Glutamatergic Synapse Elimination in the Rat Prefrontal Cortex: Establishing an Organotypic Brain Slice Culture Investigating Tool

Clinical and pre-clinical studies of neuropsychiatric (NP) disorders show altered astrocyte properties and synaptic networks. These are refined during early postnatal developmental (PND) stages. Thus, investigating early brain maturational trajectories is essential to understand NP disorders. Howeve...

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Bibliographic Details
Main Authors: Eugenia Vivi, Lea R. Seeholzer, Anastasiia Nagumanova, Barbara Di Benedetto
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
organotypic brain slice culture
astrocyte
synaptic phagocytosis
critical period
sex differences
Online Access:https://www.mdpi.com/2073-4409/12/23/2761

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https://www.mdpi.com/2073-4409/12/23/2761

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