Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice

Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice

BackgroundNeurodegenerative processes in Alzheimer’s disease (AD) are associated with excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR). D-Serine is an endogenous co-agonist necessary for NMDAR-mediated excitotoxicity. In the mammalian brain, it is produced by serine racemase (SRR...

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Bibliographic Details
Main Authors: Xiance Ni, Ran Inoue, Yi Wu, Tomoyuki Yoshida, Keisuke Yaku, Takashi Nakagawa, Takashi Saito, Takaomi C. Saido, Keizo Takao, Hisashi Mori
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
D-serine
serine racemase
excitotoxicity
neurodegeneration
amino acid homeostasis
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1211067/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1211067/full

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