Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice

Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice

BackgroundNeurodegenerative processes in Alzheimer’s disease (AD) are associated with excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR). D-Serine is an endogenous co-agonist necessary for NMDAR-mediated excitotoxicity. In the mammalian brain, it is produced by serine racemase (SRR...

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Bibliographic Details
Main Authors:	Xiance Ni, Ran Inoue, Yi Wu, Tomoyuki Yoshida, Keisuke Yaku, Takashi Nakagawa, Takashi Saito, Takaomi C. Saido, Keizo Takao, Hisashi Mori
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-06-01
Series:	Frontiers in Aging Neuroscience
Subjects:	Alzheimer’s disease D-serine serine racemase excitotoxicity neurodegeneration amino acid homeostasis
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2023.1211067/full

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