Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell

Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell

Abstract Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli. RTX proteins are secreted via Type I secretion systems (T1SS) and adopt their native conformation in the Ca2+-rich extracellular environme...

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Bibliographic Details
Main Authors: Isabelle N. Erenburg, Sebastian Hänsch, Feby M. Chacko, Anna Hamacher, Sebastian Wintgens, Fabian Stuhldreier, Gereon Poschmann, Olivia Spitz, Kai Stühler, Sebastian Wesselborg, Johannes H. Hegemann, Sander H. J. Smits, Stefanie Weidtkamp-Peters, Lutz Schmitt
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-22480-x

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https://doi.org/10.1038/s41598-022-22480-x

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