Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells

Low-dose of caffeine alleviates high altitude pulmonary edema via regulating mitochondrial quality control process in AT1 cells

Backgrounds: High-altitude pulmonary edema (HAPE) is a life-threatening disease without effective drugs. Caffeine is a small molecule compound with antioxidant biological activity used to treat respiratory distress syndrome. However, it is unclear whether caffeine plays a role in alleviating HAPE.Me...

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Bibliographic Details
Main Authors: Liuyang Tian, Zhilong Jia, Yan Yan, Qian Jia, Wenjie Shi, Saijia Cui, Huining Chen, Yang Han, Xiaojing Zhao, Kunlun He
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
caffeine
high altitude pulmonary edema (HAPE)
mitochondrial
mitochondrial quality control
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1155414/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1155414/full

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