Novel pathological predictive factors for extranodal extension in oral squamous cell carcinoma: a retrospective cohort study based on tumor budding, desmoplastic reaction, tumor-infiltrating lymphocytes, and depth of invasion

Novel pathological predictive factors for extranodal extension in oral squamous cell carcinoma: a retrospective cohort study based on tumor budding, desmoplastic reaction, tumor-infiltrating lymphocytes, and depth of invasion

Abstract Background Extranodal extension (ENE) is a poor prognostic factor for oral squamous cell carcinoma (OSCC). Identifying ENE by clinical and/or radiological examination is difficult, thereby leading to unnecessary neck dissections. Currently, no definitive predictors are available for ENE. Th...

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Bibliographic Details
Main Authors: Yuri Noda, Mitsuaki Ishida, Yasuhiro Ueno, Takuo Fujisawa, Hiroshi Iwai, Koji Tsuta
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Cancer
Subjects:
Extranodal extension
Oral squamous cell carcinoma
Tumor budding
Desmoplastic reaction
Tumor-infiltrating lymphocytes
Predictor
Online Access:https://doi.org/10.1186/s12885-022-09393-8

Internet

https://doi.org/10.1186/s12885-022-09393-8

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