Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease

Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a trinucleotide (CAG) repeat expansion in the huntingtin gene (HTT). The R6/2 transgenic mouse model of HD expresses exon 1 of the human HTT gene with approximately 150 CAG repeats. R6/2 mice develop progressive beha...

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Bibliographic Details
Main Authors: Simone Rolfes, David A.D. Munro, Ekaterini-Maria Lyras, Eduardo Matute, Koliane Ouk, Christoph Harms, Chotima Böttcher, Josef Priller
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Intracerebroventricular
Gene delivery
Transgenic mice
Therapy
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120302990

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http://www.sciencedirect.com/science/article/pii/S0969996120302990

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