Alleviation of endoplasmic reticulum stress protects against cisplatin-induced ovarian damage

Alleviation of endoplasmic reticulum stress protects against cisplatin-induced ovarian damage

Abstract Background Cisplatin (CDDP), a widely used chemotherapeutic agent, can induce excessive granulosa cell apoptosis, follicle loss and even premature ovarian insufficiency (POI). However, the mechanism remains elusive, although some studies have indicated the involvement of endoplasmic reticul...

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Bibliographic Details
Main Authors: Yuping Wu, Congshun Ma, Huihui Zhao, Yuxia Zhou, Zhenguo Chen, Liping Wang
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Reproductive Biology and Endocrinology
Subjects:
Cisplatin
Endoplasmic reticulum stress
Granulosa cell apoptosis
Ovarian damage
4-PBA
Online Access:http://link.springer.com/article/10.1186/s12958-018-0404-4

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http://link.springer.com/article/10.1186/s12958-018-0404-4

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