Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens
The effect of two different contamination levels of T-2 toxin (1.5 or 3.4 mg/kg feed) was investigated in a 28-days feeding trial on body weight, relative weight of liver and spleen, and some lipid peroxidation and glutathione redox parameters of 14-days old broiler chicken. The results showed that...
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| Format: | Article |
| Language: | English |
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Japan Poultry Science Association
2015-07-01
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| Series: | The Journal of Poultry Science |
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| Online Access: | https://www.jstage.jst.go.jp/article/jpsa/52/3/52_0140147/_pdf/-char/en |
| _version_ | 1827938929345560576 |
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| author | Krisztián Balogh Andrea Bócsai Csilla Pelyhe Erika Zándoki Márta Erdélyi Judit Szabó-Fodor Miklós Mézes |
| author_facet | Krisztián Balogh Andrea Bócsai Csilla Pelyhe Erika Zándoki Márta Erdélyi Judit Szabó-Fodor Miklós Mézes |
| author_sort | Krisztián Balogh |
| collection | DOAJ |
| description | The effect of two different contamination levels of T-2 toxin (1.5 or 3.4 mg/kg feed) was investigated in a 28-days feeding trial on body weight, relative weight of liver and spleen, and some lipid peroxidation and glutathione redox parameters of 14-days old broiler chicken. The results showed that T-2 toxin decreased significantly the body weight at both contamination levels and showed a dose-dependent tendency. Relative weight of liver increased till the end of the trial, while relative weight of spleen was lower at both samplings at lower level of T-2 toxin exposure. Initial phase of lipid peroxidation (conjugated dienes and trienes) was not detected in the liver, but as product of later phase, thiobarbituric acid reactive substances increased significantly, except in the liver. Glutathione content on day 14 was higher in liver homogenate as compared to the control at the lower T-2 toxin contamination level. On day 28 it was higher in blood plasma at the higher and in liver homogenate at both levels of T-2 contamination. Glutathione peroxidase activity on day 14 was significantly higher in liver and spleen homogenates as compared to the control at the lower level of T-2 toxin contamination. On day 28, significantly higher activity was found at both T-2 toxin contamination levels in liver homogenate, and at the lower contamination level in spleen homogenate as compared to the control.The results revealed that T-2 toxin exposure initiates lipid peroxidation and activates the glutathione redox system as well, but the changes were irrespective of the dose- and partly duration of the exposure. |
| first_indexed | 2024-03-13T08:45:57Z |
| format | Article |
| id | doaj.art-37ceff2a172c476fbe95d526cca4b8f3 |
| institution | Directory Open Access Journal |
| issn | 1346-7395 1349-0486 |
| language | English |
| last_indexed | 2024-03-13T08:45:57Z |
| publishDate | 2015-07-01 |
| publisher | Japan Poultry Science Association |
| record_format | Article |
| series | The Journal of Poultry Science |
| spelling | doaj.art-37ceff2a172c476fbe95d526cca4b8f32023-05-30T04:33:40ZengJapan Poultry Science AssociationThe Journal of Poultry Science1346-73951349-04862015-07-0152317618210.2141/jpsa.0140147jpsaEffects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler ChickensKrisztián Balogh0Andrea Bócsai1Csilla Pelyhe2Erika Zándoki3Márta Erdélyi4Judit Szabó-Fodor5Miklós Mézes6Department of Nutrition, Szent István University, HungaryDepartment of Nutrition, Szent István University, HungaryDepartment of Nutrition, Szent István University, HungaryHungarian Academy of Sciences - Kaposvár University “MTA-KE Mycotoxins in the Food Chain” Research Group, HungaryDepartment of Nutrition, Szent István University, HungaryHungarian Academy of Sciences - Kaposvár University “MTA-KE Mycotoxins in the Food Chain” Research Group, HungaryDepartment of Nutrition, Szent István University, HungaryThe effect of two different contamination levels of T-2 toxin (1.5 or 3.4 mg/kg feed) was investigated in a 28-days feeding trial on body weight, relative weight of liver and spleen, and some lipid peroxidation and glutathione redox parameters of 14-days old broiler chicken. The results showed that T-2 toxin decreased significantly the body weight at both contamination levels and showed a dose-dependent tendency. Relative weight of liver increased till the end of the trial, while relative weight of spleen was lower at both samplings at lower level of T-2 toxin exposure. Initial phase of lipid peroxidation (conjugated dienes and trienes) was not detected in the liver, but as product of later phase, thiobarbituric acid reactive substances increased significantly, except in the liver. Glutathione content on day 14 was higher in liver homogenate as compared to the control at the lower T-2 toxin contamination level. On day 28 it was higher in blood plasma at the higher and in liver homogenate at both levels of T-2 contamination. Glutathione peroxidase activity on day 14 was significantly higher in liver and spleen homogenates as compared to the control at the lower level of T-2 toxin contamination. On day 28, significantly higher activity was found at both T-2 toxin contamination levels in liver homogenate, and at the lower contamination level in spleen homogenate as compared to the control.The results revealed that T-2 toxin exposure initiates lipid peroxidation and activates the glutathione redox system as well, but the changes were irrespective of the dose- and partly duration of the exposure.https://www.jstage.jst.go.jp/article/jpsa/52/3/52_0140147/_pdf/-char/enbroilerglutathioneglutathione peroxidaselipid peroxidationt-2 toxin |
| spellingShingle | Krisztián Balogh Andrea Bócsai Csilla Pelyhe Erika Zándoki Márta Erdélyi Judit Szabó-Fodor Miklós Mézes Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens The Journal of Poultry Science broiler glutathione glutathione peroxidase lipid peroxidation t-2 toxin |
| title | Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens |
| title_full | Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens |
| title_fullStr | Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens |
| title_full_unstemmed | Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens |
| title_short | Effects of Long-term Feeding of Graded Levels of T-2 Toxin-contaminated Diets on Performance, Some Lipid Peroxide and Glutathione Redox Status Parameters of Broiler Chickens |
| title_sort | effects of long term feeding of graded levels of t 2 toxin contaminated diets on performance some lipid peroxide and glutathione redox status parameters of broiler chickens |
| topic | broiler glutathione glutathione peroxidase lipid peroxidation t-2 toxin |
| url | https://www.jstage.jst.go.jp/article/jpsa/52/3/52_0140147/_pdf/-char/en |
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