Improvement in Solubility–Permeability Interplay of Psoralens from <i>Brosimum gaudichaudii</i> Plant Extract upon Complexation with Hydroxypropyl-β-cyclodextrin

Improvement in Solubility–Permeability Interplay of Psoralens from <i>Brosimum gaudichaudii</i> Plant Extract upon Complexation with Hydroxypropyl-β-cyclodextrin

Psoralen (PSO) and 5-methoxypsoralen (5-MOP) are widely used drugs in oral photochemotherapy against vitiligo and major bioactive components of root bark extract of <i>Brosimum gaudichaudii</i> Trécul (EBGT), previously standardized by LC-MS. However, the exceptionally low water solubili...

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Bibliographic Details
Main Authors: Rúbia Darc Machado, Júlio C. G. Silva, Luís A. D. Silva, Gerlon de A. R. Oliveira, Luciano M. Lião, Eliana M. Lima, Mariana C. de Morais, Edemilson C. da Conceição, Kênnia R. Rezende
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
cyclodextrin
HP-β-CD
inclusion complexes
physical–chemical characterization
host–guest interaction
solubilization
Online Access:https://www.mdpi.com/1420-3049/27/14/4580

Internet

https://www.mdpi.com/1420-3049/27/14/4580

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