mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies

mRNA lipid nanoparticles expressing cell-surface cleavage independent HIV Env trimers elicit autologous tier-2 neutralizing antibodies

The HIV-1 envelope glycoprotein (Env) is the sole neutralizing determinant on the surface of the virus. The Env gp120 and gp41 subunits mediate receptor binding and membrane fusion and are generated from the gp160 precursor by cellular furins. This cleavage event is required for viral entry. One app...

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Bibliographic Details
Main Authors: Javier Guenaga, Mehrdad Alirezaei, Yu Feng, Mohamad-Gabriel Alameh, Wen-Hsin Lee, Sabyasachi Baboo, Jocelyn Cluff, Richard Wilson, Shridhar Bale, Gabriel Ozorowski, Paulo Lin, Ying Tam, Jolene K. Diedrich, John R. Yates, James C. Paulson, Andrew B. Ward, Drew Weissman, Richard T. Wyatt
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-07-01
Series:Frontiers in Immunology
Subjects:
HIV
vaccine
mRNA
NFL
SOSIP
Env
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1426232/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1426232/full

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