Analysis of Human Clinical Mutations of Mitochondrial ND1 in a Bacterial Model System for Complex I

The most common causes of mitochondrial dysfunction and disease include mutations in subunits and assembly factors of Complex I. Numerous mutations in the mitochondrial gene ND1 have been identified in humans. Currently, a bacterial model system provides the only method for rapid construction and an...

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Bibliographic Details
Main Authors: Hind A. Alkhaldi, Duong H. Phan, Steven B. Vik
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Life
Subjects:
Online Access:https://www.mdpi.com/2075-1729/12/11/1934