Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression

Wnt5a-induced M2 polarization of tumor-associated macrophages via IL-10 promotes colorectal cancer progression

Abstract Background Tumor-associated macrophages (TAMs) in the tumor microenvironment influence tumor initiation, invasion and metastasis. Several studies have shown that Wnt5a is mainly expressed in the tumor stroma, especially in TAMs. However, whether Wnt5a regulates the polarization and biologic...

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Bibliographic Details
Main Authors: Qing Liu, Chaogang Yang, Shuyi Wang, Dongdong Shi, Chen Wei, Jialin Song, Xiaobin Lin, Rongzhang Dou, Jian Bai, Zhenxian Xiang, Sihao Huang, Keshu Liu, Bin Xiong
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cell Communication and Signaling
Subjects:
Tumor-associated macrophages
Wnt5a
IL-10
M2 polarization
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s12964-020-00557-2

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http://link.springer.com/article/10.1186/s12964-020-00557-2

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