Cooperative effects of oocytes and estrogen on the forkhead box L2 expression in mural granulosa cells in mice

Abstract Forkhead box L2 (FOXL2) plays a critical role in the development and function of mammalian ovaries. In fact, the causative effects of FOXL2 misregulations have been identified in many ovarian diseases, such as primary ovarian insufficiency and granulosa cell tumor; however, the mechanism by...

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Bibliographic Details
Main Authors: Haruka Ito, Chihiro Emori, Mei Kobayashi, Natsumi Maruyama, Wataru Fujii, Kunihiko Naito, Koji Sugiura
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24680-x