The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer

The PIK3CA E542K and E545K mutations promote glycolysis and proliferation via induction of the β-catenin/SIRT3 signaling pathway in cervical cancer

Abstract Background The study aims to present the effect of PIK3CA E542K and E545K mutations on glucose metabolism and proliferation and identify their underlying mechanisms in cervical cancer. Methods The maximum standard uptake value (SUVmax) of tumors was detected by18F-FDG PET/CT scan. In vitro,...

Full description

Bibliographic Details
Main Authors: Wei Jiang, Tiancong He, Shuai Liu, Yingying Zheng, Libing Xiang, Xuan Pei, Ziliang Wang, Huijuan Yang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Journal of Hematology & Oncology
Subjects:
PIK3CA E542K and E545K mutations
β-Catenin
SIRT3
Glycolysis
Cervical cancer
Online Access:http://link.springer.com/article/10.1186/s13045-018-0674-5

Internet

http://link.springer.com/article/10.1186/s13045-018-0674-5

Similar Items