Mutant TDP-43 deregulates AMPK activation by PP2A in ALS models.
Bioenergetic abnormalities and metabolic dysfunctionoccur in amyotrophic lateral sclerosis (ALS) patients and genetic mouse models. However, whether metabolic dysfunction occurs earlyin ALS pathophysiology linked to different ALS genes remains unclear.Here, we investigatedAMP-activated protein kinas...
| Auteurs principaux: | , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Public Library of Science (PLoS)
2014-01-01
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| Collection: | PLoS ONE |
| Accès en ligne: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090449&type=printable |