Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin.

Insulin/IGF-I signaling pathways enhances tumor cell invasion through bisecting GlcNAc N-glycans modulation. an interplay with E-cadherin.

Changes in glycosylation are considered a hallmark of cancer, and one of the key targets of glycosylation modifications is E-cadherin. We and others have previously demonstrated that E-cadherin has a role in the regulation of bisecting GlcNAc N-glycans expression, remaining to be determined the E-ca...

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Bibliographic Details
Main Authors: Julio Cesar Madureira de-Freitas-Junior, Sandra Carvalho, Ana M Dias, Patrícia Oliveira, Joana Cabral, Raquel Seruca, Carla Oliveira, José Andrés Morgado-Díaz, Celso A Reis, Salomé S Pinho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3839884?pdf=render

Internet

http://europepmc.org/articles/PMC3839884?pdf=render

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