Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis

Using Structure-guided Fragment-Based Drug Discovery to Target Pseudomonas aeruginosa Infections in Cystic Fibrosis

Cystic fibrosis (CF) is progressive genetic disease that predisposes lungs and other organs to multiple long-lasting microbial infections. Pseudomonas aeruginosa is the most prevalent and deadly pathogen among these microbes. Lung function of CF patients worsens following chronic infections with P....

Full description

Bibliographic Details
Main Authors: Sheikh Mohammed Arif, R. Andres Floto, Tom L. Blundell
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
FBDD
fragment-based drug discovery
antibiotics
cystic fibrosis
Pseudomonas
anti-virulence
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.857000/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.857000/full

Similar Items