CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability

CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability

Abstract Chromobox protein homolog 4 (CBX4) is a component of the Polycomb group (PcG) multiprotein Polycomb repressive complexes 1 (PRC1), which is participated in several processes including growth, senescence, immunity, and tissue repair. CBX4 has been shown to have diverse, even opposite functio...

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Bibliographic Details
Main Authors: Fangzhen Chen, Wulei Hou, Xiangtian Yu, Jing Wu, Zhengda Li, Jietian Xu, Zimu Deng, Gaobin Chen, Bo Liu, Xiaoxing Yin, Wei Yu, Lei Zhang, Guoliang Xu, Hongbin Ji, Chunmin Liang, Zuoyun Wang
Format: Article
Language:English
Published: Nature Publishing Group 2023-09-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-023-01623-0

Internet

https://doi.org/10.1038/s41392-023-01623-0

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