A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis

A physiologically based pharmacokinetic/pharmacodynamic model to determine dosage regimens and withdrawal intervals of aditoprim against Streptococcus suis

Introduction: Streptococcus suis (S. suis) is a zoonotic pathogen threatening public health. Aditoprim (ADP), a novel veterinary medicine, exhibits an antibacterial effect against S. suis. In this study, a physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) model was used to determine th...

Full description

Bibliographic Details
Main Authors: Kun Mi, Lei Sun, Lan Zhang, Aoran Tang, Xiaoyuan Tian, Yixuan Hou, Lingling Sun, Lingli Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Pharmacology
Subjects:
PBPK model
semi-mechanistic PD model
aditoprim
Streptococcus suis
dosage regimen
withdrawal interval
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1378034/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1378034/full

Similar Items