Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells

Amyloidogenic protein aggregation impairs cell function and is a hallmark of many chronic degenerative disorders. Protein aggregation is also a major event during acute injury; however, unlike amyloidogenesis, the process of injury-induced protein aggregation remains largely undefined. To provide th...

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Bibliographic Details
Main Authors: Andre L. Samson, Bosco Ho, Amanda E. Au, Simone M. Schoenwaelder, Mark J. Smyth, Stephen P. Bottomley, Oded Kleifeld, Robert L. Medcalf
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Open Biology
Subjects:
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160098