IgM repertoire biodiversity is reduced in HIV-1 infection and systemic lupus erythematosus

IgM repertoire biodiversity is reduced in HIV-1 infection and systemic lupus erythematosus

Background: HIV-1 infection or systemic lupus erythematosus [SLE] disrupt B cell homeostasis, reduce memory B cells, and impair function of IgG and IgM antibodies. Objective: To determine how disturbances in B cell populations producing polyclonal antibodies relate to the IgM repertoire, the IgM tra...

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Bibliographic Details
Main Authors: Li eYin, Wei eHou, Li eLiu, Yunpeng eCai, Mark Andrew Wallet, Brent Paul Gardner, Kaifen eChang, Amanda Catherine Lowe, Carina Adriana Rodriguez, Panida eSriaroon, William George Farmerie, John William Sleasman, Maureen Michels Goodenow
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
HIV-1
pyrosequencing
Biodiversity
somatic hypermutation
systemic lupus erythematosus
IgM memory B cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00373/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00373/full

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