Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response

Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response

Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser784 phosphorylation specifically increases VCP function for the DNA damage r...

Full description

Bibliographic Details
Main Author:	Jieya Shao
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2020-09-01
Series:	Molecular & Cellular Oncology
Subjects:	proteostasis dna damage response chemotherapy phosphorylation prognostic biomarker
Online Access:	http://dx.doi.org/10.1080/23723556.2020.1796179

Similar Items

Phospho-Ser<sup>784</sup>-VCP Drives Resistance of Pancreatic Ductal Adenocarcinoma to Genotoxic Chemotherapies and Predicts the Chemo-Sensitizing Effect of VCP Inhibitor
by: Faliang Wang, et al.
Published: (2021-10-01)

Coordinate to guard: crosstalk of phosphorylation, sumoylation and ubiquitylation in DNA damage response
by: Ching-Ying eKuo, et al.
Published: (2012-01-01)

Response to DNA damage: why do we need to focus on protein phosphatases?
by: Midori eShimada, et al.
Published: (2013-01-01)

Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence
by: Ying Ao, et al.
Published: (2023-02-01)

It takes two to tango: Ubiquitin and SUMO in the DNA damage response
by: Serena eBologna, et al.
Published: (2013-06-01)

VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage
by: Raúl García-González, et al.
Published: (2020-10-01)

Phosphorylation of FtsZ and FtsA by a DNA Damage-Responsive Ser/Thr Protein Kinase Affects Their Functional Interactions in <italic toggle="yes">Deinococcus radiodurans</italic>
by: Ganesh K. Maurya, et al.
Published: (2018-08-01)

FtsZ phosphorylation brings about growth arrest upon DNA damage in Deinococcus radiodurans
by: Reema Chaudhary, et al.
Published: (2023-01-01)

MicroRNAs, DNA Damage Response, and Cancer Treatment
by: Mingyang He, et al.
Published: (2016-12-01)

DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage
by: Thom G. A. Reuvers, et al.
Published: (2020-07-01)

Genomic, Transcriptomic, and Functional Alterations in DNA Damage Response Pathways as Putative Biomarkers of Chemotherapy Response in Ovarian Cancer
by: Sweta Sharma Saha, et al.
Published: (2021-03-01)

DNA Damage Response in Cancer Therapy and Resistance: Challenges and Opportunities
by: Dana Jurkovicova, et al.
Published: (2022-11-01)

Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers
by: Martin Liptay, et al.
Published: (2020-05-01)

Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism
by: Kaspar Burger, et al.
Published: (2019-08-01)

Maintaining Genome Stability In Defiance Of Mitotic DNA Damage
by: Stefano Ferrari, et al.
Published: (2016-07-01)

Relevance of ATM Status in Driving Sensitivity to DNA Damage Response Inhibitors in Patient-Derived Xenograft Models
by: Ankur Karmokar, et al.
Published: (2023-08-01)

Divergent FUS phosphorylation in primate and mouse cells following double-strand DNA damage
by: Michelle A. Johnson, et al.
Published: (2020-12-01)

Characterization of DNA Damage Repair Related Signature and Molecular Feature in Low-Grade Gliomas to Aid Chemotherapy and Drug Discovery
by: Xin Yin, et al.
Published: (2023-10-01)

Bcl-2-associated transcription factor 1 Ser290 phosphorylation mediates DNA damage response and regulates radiosensitivity in gastric cancer
by: Jia Liu, et al.
Published: (2021-08-01)

MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment
by: Lei Bian, et al.
Published: (2019-11-01)

Screening of DNA Damage Repair Genes Involved in the Prognosis of Triple-Negative Breast Cancer Patients Based on Bioinformatics
by: Nan Wang, et al.
Published: (2021-08-01)

The multifaceted world of the DNA damage response
by: Antonio ePorro
Published: (2016-05-01)

ATM-Dependent Phosphorylation of Hepatitis B Core Protein in Response to Genotoxic Stress
by: Barbora Lubyova, et al.
Published: (2021-12-01)

DNA Electrochemical Biosensors for In Situ Probing of Pharmaceutical Drug Oxidative DNA Damage
by: Ana-Maria Chiorcea-Paquim, et al.
Published: (2021-02-01)

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization
by: Stephanie J Papp, et al.
Published: (2015-03-01)

Checkpoint Kinase 1 Pharmacological Inhibition Synergizes with DNA-Damaging Agents and Overcomes Platinum Resistance in Basal-Like Breast Cancer
by: Cristina Nieto-Jimenez, et al.
Published: (2020-11-01)

Phosphoproteomics Sample Preparation Impacts Biological Interpretation of Phosphorylation Signaling Outcomes
by: Bharath Sampadi, et al.
Published: (2021-12-01)

DNA damage response and cell cycle regulation in bacteria: a twist around the paradigm
by: Hari Sharan Misra, et al.
Published: (2024-03-01)

Identification of a DNA Damage Response and Repair-Related Gene-Pair Signature for Prognosis Stratification Analysis in Hepatocellular Carcinoma
by: Yi Chen, et al.
Published: (2022-04-01)

The FHA domain protein ArnA functions as a global DNA damage response repressor in the hyperthermophilic archaeon Saccharolobus islandicus
by: Zhichao Jiang, et al.
Published: (2023-08-01)

A novel nomogram based on DNA damage response-related gene expression in patients with O-6-methylguanine-DNA methyltransferase unmethylated glioblastoma receiving temozolomide chemotherapy: A population-based analysis
by: Rong Wang, et al.
Published: (2022-01-01)

Phosphorylation of the human topoisomerase II protein
by: Fry, A, et al.
Published: (1992)

DNA Damage Stress Response and Follicle Activation: Signaling Routes of Mammalian Ovarian Reserve
by: Stefania Gonfloni, et al.
Published: (2022-11-01)

Clickable Cisplatin Derivatives as Versatile Tools to Probe the DNA Damage Response to Chemotherapy
by: Amandine Moretton, et al.
Published: (2022-06-01)

p97/VCP regulates MRE11-dependent DNA and resection and alters cellular toxicity of ionising radiation
by: Kilgas, S
Published: (2021)

The DNA damage response in mammalian oocytes
by: John eCarroll, et al.
Published: (2013-06-01)

Construction of a DNA damage repair gene signature for predicting prognosis and immune response in breast cancer
by: Yiming Chang, et al.
Published: (2023-01-01)

DNA Damage Response Gene-Based Subtypes Associated With Clinical Outcomes in Early-Stage Lung Adenocarcinoma
by: Yang Zhao, et al.
Published: (2022-06-01)

Multiplexed-Based Assessment of DNA Damage Response to Chemotherapies Using Cell Imaging Cytometry
by: Nadia Vezzio-Vié, et al.
Published: (2022-05-01)

Understanding DNA Damage Response and DNA Repair in Multiple Myeloma
by: Cole Petrilla, et al.
Published: (2023-08-01)