Adjuvant Activity of CpG-Oligonucleotide Administered Transcutaneously in Combination with Vaccination Using a Self-Dissolving Microneedle Patch in Mice

Adjuvant Activity of CpG-Oligonucleotide Administered Transcutaneously in Combination with Vaccination Using a Self-Dissolving Microneedle Patch in Mice

In this study, we investigated the mechanism of transcutaneous adjuvant activity of the CpG-oligonucleotide (K3) in mice. Transcutaneous immunization (TCI) with an ovalbumin-loaded self-dissolving microneedle patch (OVA-sdMN) and K3-loaded hydrophilic gel patch (HG) increased OVA-specific Th2- and T...

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Bibliographic Details
Main Authors: Sachiko Hirobe, Takuto Kawakita, Taki Yamasaki, Sayami Ito, Masashi Tachibana, Naoki Okada
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Vaccines
Subjects:
transcutaneous immunization
microneedle
TLR9 ligand
adjuvant
CpG-oligonucleotide
Online Access:https://www.mdpi.com/2076-393X/9/12/1480

Internet

https://www.mdpi.com/2076-393X/9/12/1480

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