Tumor cell enrichment by tissue suspension improves sensitivity to copy number variation in diffuse gastric cancer with low tumor content

Tumor cell enrichment by tissue suspension improves sensitivity to copy number variation in diffuse gastric cancer with low tumor content

Abstract The detection of copy number variations (CNVs) and somatic mutations in cancer is important for the selection of specific drugs for patients with cancer. In cancers with sporadic tumor cells, low tumor content prevents the accurate detection of somatic alterations using targeted sequencing....

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Bibliographic Details
Main Authors: Keiichi Hatakeyama, Koji Muramatsu, Takeshi Nagashima, Hiroyuki Ichida, Yuichi Kawanishi, Ryutaro Fukumura, Keiichi Ohshima, Yuji Shimoda, Sumiko Ohnami, Shumpei Ohnami, Koji Maruyama, Akane Naruoka, Hirotsugu Kenmotsu, Kenichi Urakami, Yasuto Akiyama, Takashi Sugino, Ken Yamaguchi
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-64541-3

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https://doi.org/10.1038/s41598-024-64541-3

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