G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ERα and ERβ in pancreatic beta cells

G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ERα and ERβ in pancreatic beta cells

17β-estradiol protects pancreatic β-cells from apoptosis via the estrogen receptors ERα, ERβ and GPER. Conversely, the endocrine disruptor bisphenol-A (BPA), which exerts multiple effects in this cell type via the same estrogen receptors, increased basal apoptosis. The molecular-initiated events tha...

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Bibliographic Details
Main Authors: Ignacio Babiloni-Chust, Reinaldo S. dos Santos, Regla M. Medina-Gali, Atenea A. Perez-Serna, José-Antonio Encinar, Juan Martinez-Pinna, Jan-Ake Gustafsson, Laura Marroqui, Angel Nadal
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Environment International
Subjects:
Apoptosis
Bisphenol-A
Endocrine disruptors
GPER/GPR30
Heterodimers
17β-estradiol
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412022001763

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http://www.sciencedirect.com/science/article/pii/S0160412022001763

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