Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice

Sex-Specific Control of Muscle Mass: Elevated IGFBP Proteolysis and Reductions of IGF-1 Levels Are Associated with Substantial Loss of Carcass Weight in Male DU6PxIGFBP-2 Transgenic Mice

In farmed animals, carcass weight represents an important economic trait. Since we had demonstrated that IGFBP-2 represents a potent inhibitor of muscle accretion in inbred mice, we wanted to quantify the inhibitory effects of IGFBP-2 under conditions of elevated protein mass in growth selected non-...

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Bibliographic Details
Main Authors: Daniela Ohde, Michael Walz, Christina Walz, Antonia Noce, Julia Brenmoehl, Martina Langhammer, Andreas Hoeflich
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
IGFBP-2
sex
transgenic mouse
phenotype selection
muscle accretion
carcass weight
Online Access:https://www.mdpi.com/2073-4409/9/10/2174

Internet

https://www.mdpi.com/2073-4409/9/10/2174

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