Autoantibodies against the glial glutamate transporter GLT1/EAAT2 in Type 1 diabetes mellitus—Clues to novel immunological and non-immunological therapies

Autoantibodies against the glial glutamate transporter GLT1/EAAT2 in Type 1 diabetes mellitus—Clues to novel immunological and non-immunological therapies

Islet cell surface autoantibodies were previously found in subjects with type 1 diabetes mellitus (T1DM), but their target antigens and pathogenic mechanisms remain elusive. The glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2) is expressed on the membrane of pancreatic β-cells an...

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Bibliographic Details
Main Authors: Carla Perego, Eliana S. Di Cairano, Alessandra Galli, Stefania Moretti, Elena Bazzigaluppi, Victoria Frolich Centonze, Amalia Gastaldelli, Emma Assi, Paolo Fiorina, Massimo Federici, Ottavia Porzio, Federico Bertuzzi, Alberto M. Davalli, Franco Folli
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Pharmacological Research
Subjects:
Autoantibody
Type 1 diabetes mellitus
EAAT2/GLT1
Complement pathway
Glutamate toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661822000755

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http://www.sciencedirect.com/science/article/pii/S1043661822000755

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