Cell-selective proteomics segregates pancreatic cancer subtypes by extracellular proteins in tumors and circulation

Abstract Cell-selective proteomics is a powerful emerging concept to study heterocellular processes in tissues. However, its high potential to identify non-cell-autonomous disease mechanisms and biomarkers has been hindered by low proteome coverage. Here, we address this limitation and devise a comp...

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Bibliographic Details
Main Authors: Jonathan J. Swietlik, Stefanie Bärthel, Chiara Falcomatà, Diana Fink, Ankit Sinha, Jingyuan Cheng, Stefan Ebner, Peter Landgraf, Daniela C. Dieterich, Henrik Daub, Dieter Saur, Felix Meissner
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38171-8