Design and Characterization of Mutated Variants of the Oncotoxic Parvoviral Protein NS1

Oncotoxic proteins such as the non-structural protein 1 (NS1), a constituent of the rodent parvovirus H1 (H1-PV), offer a novel approach for treatment of tumors that are refractory to other treatments. In the present study, mutated NS1 variants were designed and tested with respect to their oncotoxi...

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Bibliographic Details
Main Authors: Patrick Hauswirth, Philipp Graber, Katarzyna Buczak, Riccardo Vincenzo Mancuso, Susanne Heidi Schenk, Jürg P. F. Nüesch, Jörg Huwyler
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/15/1/209