A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2’-deoxycytidines

A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2’-deoxycytidines

Aptamers constitute an answer for the growing need for targeted therapy development. One of the most well-known representatives of this group of compounds is thrombin binding aptamers (TBA) targeted towards thrombin. The TBA inhibitory activity is determined by its spatial arrangement, which consist...

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Bibliografiska uppgifter
Huvudupphovsmän:	Weronika Kotkowiak, Zofia Jahnz-Wechmann, Anna Pasternak
Materialtyp:	Artikel
Språk:	English
Publicerad:	MDPI AG 2021-12-01
Serie:	Pharmaceuticals
Ämnen:	G-quadruplex thrombin binding aptamer thermodynamics circular dichroism anticoagulant activity anticancer agents
Länkar:	https://www.mdpi.com/1424-8247/14/12/1326

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