A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2’-deoxycytidines
Aptamers constitute an answer for the growing need for targeted therapy development. One of the most well-known representatives of this group of compounds is thrombin binding aptamers (TBA) targeted towards thrombin. The TBA inhibitory activity is determined by its spatial arrangement, which consist...
المؤلفون الرئيسيون: | Weronika Kotkowiak, Zofia Jahnz-Wechmann, Anna Pasternak |
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التنسيق: | مقال |
اللغة: | English |
منشور في: |
MDPI AG
2021-12-01
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سلاسل: | Pharmaceuticals |
الموضوعات: | |
الوصول للمادة أونلاين: | https://www.mdpi.com/1424-8247/14/12/1326 |
مواد مشابهة
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Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative
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Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core
حسب: Julia Svetlova, وآخرون
منشور في: (2021-09-01) -
Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12
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منشور في: (2021-03-01) -
The Regioselective Conjugation of the 15-nt Thrombin Aptamer with an Optimized Tripeptide Sequence Greatly Increases the Anticoagulant Activity of the Aptamer
حسب: Irina V. Varizhuk, وآخرون
منشور في: (2023-02-01) -
Design strategy of antidote sequence for bivalent aptamer: Rapid neutralization of high‐anticoagulant thrombin‐binding bivalent DNA aptamer‐linked M08 with HD22
حسب: Toru Yoshitomi, وآخرون
منشور في: (2021-07-01)