Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming

Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming

Abstract In optic neuropathies, including glaucoma, retinal ganglion cells (RGCs) die. Cell transplantation and endogenous regeneration offer strategies for retinal repair, however, developmental programs required for this to succeed are incompletely understood. To address this, we explored cellular...

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Bibliographic Details
Main Authors: Devansh Agarwal, Nicholas Dash, Kevin W. Mazo, Manan Chopra, Maria P. Avila, Amit Patel, Ryan M. Wong, Cairang Jia, Hope Do, Jie Cheng, Colette Chiang, Shawna L. Jurlina, Mona Roshan, Michael W. Perry, Jong M. Rho, Risa Broyer, Cassidy D. Lee, Robert N. Weinreb, Cezar Gavrilovici, Nicholas W. Oesch, Derek S. Welsbie, Karl J. Wahlin
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-023-00327-x

Internet

https://doi.org/10.1038/s41536-023-00327-x

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