Guanylyl cyclase C ameliorates visceral pain: an unsuspected link
Visceral pain associated with irritable bowel syndrome afflicts 15% of the US population. Although treatments are limited, guanylyl cyclase C (GUCY2C) agonists alleviate pain and constipation. Until now, it was assumed that the activation of GUCY2C and production of cGMP in enterocytes stimulated fl...
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2023-02-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI166703 |