The SMAC Mimetic APG-1387 Sensitizes Immune-Mediated Cell Apoptosis in Hepatocellular Carcinoma

The SMAC Mimetic APG-1387 Sensitizes Immune-Mediated Cell Apoptosis in Hepatocellular Carcinoma

The inhibitor of apoptosis protein (IAP) genes are frequently overexpressed in malignancies. Second mitochondria-derived activator of caspase (SMAC) mimetics, which target IAPs, have potential to trigger cancer cell death and sensitize tumor cells to cytotoxic therapy. The aim of this study was to i...

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Bibliographic Details
Main Authors: Zide Chen, Jiehua Chen, Hongyan Liu, Wei Dong, Xuan Huang, Dajun Yang, Jinlin Hou, Xiaoyong Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
SMAC mimetic
inhibitor of apoptosis protein
TNF-α
TRAIL
natural killer cells
cancer stem cells
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01298/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01298/full

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