The use of mice as animal model for testing acute toxicity (LD-50) of toxic shock syndrome toxin Utilização de camundongos como modelo animal para a verificação da toxicidade aguda da toxina-1 da síndrome do choque tóxico
Acute toxicity test (LD-50) using toxic shock syndrome toxin (TSST-1) was tested in BALB/c, C57BL/6 and Swiss mice. Animals (n = 10) were intraperitoneally injected with TSST-1 (0.01-10.0µg/mouse) followed 4h later by potentiating dose of lipopolysaccharide (75.0µg of LPS - E. coli O111:B4) and cumu...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Universidade Federal de Minas Gerais
2009-02-01
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Series: | Arquivo Brasileiro de Medicina Veterinária e Zootecnia |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352009000100024 |