The use of mice as animal model for testing acute toxicity (LD-50) of toxic shock syndrome toxin Utilização de camundongos como modelo animal para a verificação da toxicidade aguda da toxina-1 da síndrome do choque tóxico

The use of mice as animal model for testing acute toxicity (LD-50) of toxic shock syndrome toxin Utilização de camundongos como modelo animal para a verificação da toxicidade aguda da toxina-1 da síndrome do choque tóxico

Acute toxicity test (LD-50) using toxic shock syndrome toxin (TSST-1) was tested in BALB/c, C57BL/6 and Swiss mice. Animals (n = 10) were intraperitoneally injected with TSST-1 (0.01-10.0µg/mouse) followed 4h later by potentiating dose of lipopolysaccharide (75.0µg of LPS - E. coli O111:B4) and cumu...

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Bibliographic Details
Main Authors: R.S. Dias, L.S. Carmo, L.G.D. Heneine, P.H. Rocha, C.F. Barbosa, R.J. Rodrigues, V.R. Linardi
Format: Article
Language:English
Published: Universidade Federal de Minas Gerais 2009-02-01
Series:Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Subjects:
camundongo
TSST-1
toxicidade aguda (DL-50)
Staphylococcus
mice
acute toxicity (LD-50)
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352009000100024

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