Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation

Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation

ABSTRACTType 2 NADH dehydrogenase (Ndh-2) is an oxidative phosphorylation enzyme discussed as a promising drug target in different pathogens, including Plasmodium falciparum and Mycobacterium tuberculosis (Mtb). To kill Mtb, Ndh-2 needs to be inactivated together with the alternative enzyme type 1 N...

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Bibliographic Details
Main Authors: Yuanyuan Xu, Sabine Ehrt, Dirk Schnappinger, Tiago Beites
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
Mycobacterium tuberculosis
antimicrobial activity
pathogenesis
respiration
nicotinamide adenine dinucleotide
Online Access:https://journals.asm.org/doi/10.1128/mbio.01045-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01045-23

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