Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

Mammalian NOTCH1-4 receptors are all associated with human malignancy, although exact roles remain enigmatic. Here we employ glp-1(ar202), a temperature-sensitive gain-of-function C. elegans NOTCH mutant, to delineate NOTCH-driven tumor responses to radiotherapy. At ≤20°C, glp-1(ar202) is wild-type,...

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Bibliographic Details
Main Authors: Xinzhu Deng, David Michaelson, Jason Tchieu, Jin Cheng, Diana Rothenstein, Regina Feldman, Sang-gyu Lee, John Fuller, Adriana Haimovitz-Friedman, Lorenz Studer, Simon Powell, Zvi Fuks, E Jane Albert Hubbard, Richard Kolesnick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4485896?pdf=render

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http://europepmc.org/articles/PMC4485896?pdf=render

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