Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Abstract Background Immunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors carry a high number of mutations, which are predicted to translate into a wide array of neoepitopes; however, a systematic classification of...

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Bibliographic Details
Main Authors: Giuseppe Rospo, Rosaria Chilà, Vittoria Matafora, Veronica Basso, Simona Lamba, Alice Bartolini, Angela Bachi, Federica Di Nicolantonio, Anna Mondino, Giovanni Germano, Alberto Bardelli
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Medicine
Subjects:
Colorectal cancer
Mismatch repair
Neoantigens
Non-coding DNA
Non-canonical antigens
Immune surveillance
Online Access:https://doi.org/10.1186/s13073-023-01275-3

Internet

https://doi.org/10.1186/s13073-023-01275-3

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