Spinochrome D Attenuates Doxorubicin-Induced Cardiomyocyte Death via Improving Glutathione Metabolism and Attenuating Oxidative Stress

Spinochrome D Attenuates Doxorubicin-Induced Cardiomyocyte Death via Improving Glutathione Metabolism and Attenuating Oxidative Stress

Doxorubicin, an anthracycline from <i>Streptomyces peucetius</i>, exhibits antitumor activity against various cancers. However, doxorubicin is cardiotoxic at cumulative doses, causing increases in intracellular reactive oxygen species in the heart. Spinochrome D (SpD) has a structure of...

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Bibliographic Details
Main Authors: Chang Shin Yoon, Hyoung Kyu Kim, Natalia P. Mishchenko, Elena A. Vasileva, Sergey A. Fedoreyev, Valentin A. Stonik, Jin Han
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Marine Drugs
Subjects:
Spinochrome D
doxorubicin
cardioprotective effect
Online Access:https://www.mdpi.com/1660-3397/17/1/2

Internet

https://www.mdpi.com/1660-3397/17/1/2

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