Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system

Mechanistic modeling explains the production dynamics of recombinant adeno-associated virus with the baculovirus expression vector system

Current manufacturing processes for recombinant adeno-associated viruses (rAAVs) have less-than-desired yields and produce significant amounts of empty capsids. The increasing demand and the high cost of goods for rAAV-based gene therapies motivate development of more efficient manufacturing process...

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Bibliographic Details
Main Authors: Francesco Destro, John Joseph, Prasanna Srinivasan, Joshua M. Kanter, Caleb Neufeld, Jacqueline M. Wolfrum, Paul W. Barone, Stacy L. Springs, Anthony J. Sinskey, Sylvain Cecchini, Robert M. Kotin, Richard D. Braatz
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
gene therapy
viral vector
mechanistic modeling
biomanufacturing
baculovirus expression vector system
AAV-based gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050123000815

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http://www.sciencedirect.com/science/article/pii/S2329050123000815

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