Conformational heterogeneity of Savinase from NMR, HDX-MS and X-ray diffraction analysis

Conformational heterogeneity of Savinase from NMR, HDX-MS and X-ray diffraction analysis

Background Several examples have emerged of enzymes where slow conformational changes are of key importance for function and where low populated conformations in the resting enzyme resemble the conformations of intermediate states in the catalytic process. Previous work on the subtilisin protease, S...

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Bibliographic Details
Main Authors: Shanshan Wu, Tam T.T.N. Nguyen, Olga V. Moroz, Johan P. Turkenburg, Jens E. Nielsen, Keith S. Wilson, Kasper D. Rand, Kaare Teilum
Format: Article
Language:English
Published: PeerJ Inc. 2020-06-01
Series:PeerJ
Subjects:
Protein dynamics
Hydrogen exchange
Mass spectrometry
NMR spectroscopy
X-ray crystallography
Online Access:https://peerj.com/articles/9408.pdf

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https://peerj.com/articles/9408.pdf

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