Peptidoglycan mediates Leptospira outer membrane protein Loa22 to toll-like receptor 2 for inflammatory interaction: a novel innate immune recognition

Abstract Leptospirosis is an overlooked zoonotic disease caused by pathogenic Leptospira depended on virulence of Leptospira and the host–pathogen interaction. Kidney is the major organ infected by Leptospira which causes tubulointerstitial nephritis. Leptospira outer membrane contains several virul...

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Bibliographic Details
Main Authors: Shen-Hsing Hsu, Ming-Yang Chang, Shih-Ming Lin, Yi-Ching Ko, Li-Feng Chou, Ya-Chung Tian, Cheng-Chieh Hung, Chih-Wei Yang
Format: Article
Language:English
Published: Nature Portfolio 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79662-8