Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant <it>BRAF</it> and wildtype <it>PTEN</it> status

Sensitivity to the MEK inhibitor E6201 in melanoma cells is associated with mutant <it>BRAF</it> and wildtype <it>PTEN</it> status

<p>Abstract</p> <p>Background</p> <p>Melanoma is the most lethal form of skin cancer, but recent advances in molecularly targeted agents against the Ras/Raf/MAPK pathway demonstrate promise as effective therapies. Despite these advances, resistance remains an issue, as...

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Bibliographic Details
Main Authors: Byron Sara A, Loch David C, Wellens Candice L, Wortmann Andreas, Wu Jiayi, Wang John, Nomoto Kenichi, Pollock Pamela M
Format: Article
Language:English
Published: BMC 2012-10-01
Series:Molecular Cancer
Subjects:
Melanoma
<it>BRAF</it>
<it>PTEN</it>
MEK inhibition
E6201
PI3K
MAPK
Online Access:http://www.molecular-cancer.com/content/11/1/75

Internet

http://www.molecular-cancer.com/content/11/1/75

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