Murepavadin, a Small Molecule Host Defense Peptide Mimetic, Activates Mast Cells via MRGPRX2 and MrgprB2

Murepavadin, a Small Molecule Host Defense Peptide Mimetic, Activates Mast Cells via MRGPRX2 and MrgprB2

Pseudomonas aeruginosa is a frequent cause of hospital-acquired wound infection and is difficult to treat because it forms biofilms and displays antibiotic resistance. Previous studies in mice demonstrated that mast cells (MCs) not only contribute to P. aeruginosa eradication but also promote wound...

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Bibliographic Details
Main Authors: Aetas Amponnawarat, Chalatip Chompunud Na Ayudhya, Hydar Ali
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
murepavadin
mast cells
MrgprB2
MRGPRX2
host defense peptides
antimicrobial peptides
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.689410/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.689410/full

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